4 展 望

线粒体分裂在胶质瘤中增强，因为分裂参与迁移和侵袭，以及干细胞的维持，是胶质瘤发展的中心。因此，分裂应被认为是胶质瘤细胞的恶性优势。这些信息应该用于临床，例如，开发准确和新颖的基于Drp1的预后生物标记物。由于Drp1参与了胶质瘤形成的显著过程，而且也是一个连续的参数，因此，它不仅对预后有帮助，而且在分级中也是有用的。因此，在这方面的研究可能是为了建立胶质瘤分级与Drp1表达、水平或磷酸化的连续体之间的相关性。此外，关于线粒体动力学失调的信息也可能用于抗肿瘤药物的开发，因为阻断胶质瘤细胞的分裂可能是有用的。重要的是，这种抑制可能是选择性的，因为阻碍神经元的分裂将对突触产生致命的影响。有趣的是，Drp1还参与过氧化物酶体的分裂，据报道这些细胞器具有致瘤作用。总之，线粒体分裂可作为抑制胶质瘤的一个重要方向，未来值得研究。

[1]BHARGAVA P,SCHNELLMANN R energetics in the kidney[J].Nature Reviews Nephrology,2017，13(10):629

[2]EMELYANOVA L,PRESTON C,GUPTA A,et of aging on mitochondrial energetics in the human atria[J].The Journals of Gerontology Series A，Biological Sciences and Medical Sciences,2018，73(5):608

[3]VYAS S，ZAGANJOR E，HAIGIS M and cancer[J].Cell，2016，166(3):555

[4]SANCHIS-GOMAR F,DERBR fission and fusion in human diseases[J].N Engl J Med,2014，370(11):1073

[5]OHBA Y，MACVICAR T，LANGER of mitochondrial plasticity by the i-AAA protease YME1L[J].Biol Chem,2020，401(6-7):877

[6]LEE Y J,KIM G H,PARK S I,et of the mitochondrial i-AAA protease YME1L induces muscle atrophy via FoxO3a and myostatin activation[J].J Cell Mol Med,2020，24(1):899

[7]OSTROM Q T,BAUCHET L,DAVIS F G,et al.The epidemiology of glioma in adults: a “state of the science” review[J].Neuro-oncology,2014，16(7):896

[8]YIN M,LU Q,LIU X,WANG T,et Drp1 inhibits glioma cells proliferation and invasion by RHOA/ ROCK1 pathway[J].Biochem Biophys Res Commun,2016，478(2):663

[9]BROSSIER N M，GUTMANN D outcomes for neurofibromatosis 1-associated brain tumors[J].Expert Review of Anticancer Therapy,2015，15(4):415

[10]NIESS H，CAMAJ P，RENNER A,et al.Side population cells of pancreatic cancer show characteristics of cancer stem cells responsible for resistance and metastasis[J].Targeted Oncology,2015，10(2):215

[11]KATAJISTO P，D?HLA J，CHAFFER C L，et al.Stem apportioning of aged mitochondria between daughter cells is required for stemness[J].Science,2015，348(6232):340

[12]BERRIDGE M V，MCCONNELL M J，GRASSO C，et transfer of mitochondria between mammalian cells: beyond co-culture approaches[J].Curr Opin Genet Dev,2016，38:75

[13]JHUN B S，JIN O-UCHI，ADANIYA S M，et kinase D activation induces mitochondrial fragmentation and dysfunction in cardiomyocytes[J].J Physiol,2018，596(5):827

[14]LENNON F E，SALGIA dynamics: biology and therapy in lung cancer[J].Expert opinion on investigational drugs,2014，23(5):675

[15]LIU T，YU R，JIN S B,et al.The mitochondrial elongation factors MIEF1 and MIEF2 exert partially distinct functions in mitochondrial dynamics[J].Experimental cell Research,2013，319(18):2893

[16]OSELLAME L D，SINGH A P，STROUD D A,et and independent roles of the Drp1 adaptors Mff，MiD49 and MiD51 in mitochondrial fission[J].J Cell Sci,2016，129(11):2170

[17]HUANG F，WANG X，LOU L,et variation and source apportionment of water pollution in Qiantang River (China) using statistical techniques[J].Water Research,2010，44(5):1562

[18]LOSN O C，SONG Z，CHEN H,et al.Fis1，Mff，MiD49，and MiD51 mediate Drp1 recruitment in mitochondrial fission[J].Molecular Biology of the Cell,2013，24(5):659

[19]CANDIDO S，LUPO G，PENNISI M，et al.The analysis of miRNA expression profiling datasets reveals inverse microRNA patterns in glioblastoma and Alzheimer's disease[J].Oncol Rep,2019，42(3):911

[20]JOSEPH J V，CONROY S，PAVLOV K，et enhances migration and invasion in glioblastoma by promoting a mesenchymal shift mediated by the HIF1α-ZEB1 axis[J].Cancer Lett,2015，359(1):107

[21]GAO X，MI Y，GUO N，et in schizophrenia 1(DISC1)inhibits glioblastoma development by regulating mitochondria dynamics[J].Oncotarget,2016，7(52):

[22]KIMURA T，CUI D，KAWANO H，et expression of GINS complex is an essential step for reactivation of quiescent stem-like tumor cells within the peri-necrotic niche in human glioblastoma[J].J Cancer Res Clin Oncd,2019，145(2):363

[23]AQUILANTI E，MILLER J，SANTAGATA S，et in prognostic markers for gliomas[J].Neuro-oncology,2018,20(suppl 7):vii17

[24]TURKALP Z，KARAMCHANDANI J，DAS S.IDH mutation in glioma: new insights and promises for the future[J].JAMA Neurology,2014，71(10):1319

[25]XIE Q，WU Q，HORBINSKI C M，et control by DRP1 in brain tumor initiating cells[J].Nat Neurosci,2015，18(4):501

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